Software

We have developed a range of software tools within the MRC Integrative Epidemiology Unit. This includes:

• EpiGraphDB is a graph database drawing together a wide array of data types relevant to population health. Access is provided through an API, web application and R package.
• The IEU GWAS database provides an extensive set of openly accessible genome-wide association study datasets
  • The IEU GWAS database API provides fast programmatic access to the data
  • The ieugwaspy package provides a Python interface to the API
  • A suite of other packages have been developed for this resource within the MRC IEU
• MR-Base is an analytical platform for two-sample Mendelian randomization that utilizes the IEU GWAS database
• LD Hub is a database of GWAS summary statistics and an analytical platform for LD score regression
• MELODI is a literature mining platform to identify potential mechanistic pathways between an exposure and outcome
  • MELODI-Presto is a rapid API to support programmatic exploration of mechanistic pathways between an exposure and outcome
• FATHMM is a suite of genetic variant effect prediction algorithms
• CScape is a suite of genetic variant effect prediction algorithms for somatic mutations in cancer

We also have some legacy software developed by the group (no longer maintained).